Identification of an NF- B-Dependent Gene Network in Cells Infected by Mammalian Reovirus†
نویسندگان
چکیده
Identification of an NFB-Dependent Gene Network in Cells Infected by Mammalian Reovirus† Sean M. O’Donnell, Geoffrey H. Holm, Janene M. Pierce, Bing Tian, Melissa J. Watson,‡ Ravi S. Chari, Dean W. Ballard, Allan R. Brasier, and Terence S. Dermody* Departments of Pediatrics, Surgery, and Microbiology and Immunology and Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, and Department of Medicine and Sealy Center for Molecular Sciences, The University of Texas Medical Branch, Galveston, Texas 77555
منابع مشابه
Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus.
Reovirus infection activates NF-kappaB, which leads to programmed cell death in cultured cells and in the murine central nervous system. However, little is known about how NF-kappaB elicits this cellular response. To identify host genes activated by NF-kappaB following reovirus infection, we used HeLa cells engineered to express a degradation-resistant mutant of IkappaBalpha (mIkappaBalpha) und...
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